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KMID : 0352119920080030245
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Journal of Kyung Hee University
1992 Volume.8 No. 3 p.245 ~ p.253
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The Effect of Intravenous Injection of Lidocaine and Additional Administration of Thiopental Sodium on Blood Pressure and Heart Rate during Endotracheal Intubation
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Abstract
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Transient increases in blood pressure and hart rate following the use of laryngoscopy and endotracheal intubation are common. In most patient, these changes are well tolerated but in some patients such as those who are at risk of arterial
hypertension
and myocardial ischemia, these changes mav be detrimental. To decrease the incidnece and degree of elevation of blood pressure and heart rate following endotracheal intubation. many approaches are tried, but without satisfying results. This is to
study
the effectiveness of intravenous injection of 1% lidocaine and additional administration of thiopental sodium just prior to endotracheal intubation on cardiovascular response. For this purpose. 60 adults undergoing elective surgery are chose.
Patients were divided into 3 groups such as followings.
Group I: control and received no lidocaine and no additional administration of thiopental sodium.
Group II: received additional administration of thiopental sodium (2 mg/kg) 40 seconds before intubation.
Group III: received lidocaine (1 mg/kg) 3 minutes before intubation and additional administration of thiopental sodium (1 mg/kg) 40 seconds before intubation. Blood pressure after intubation, heart rate, and occurence of arrhythmia are observed
and
compared with preinduction values.
@ES Results are as followed.
@EN 1) In group I, the systolic blood pressure during endotracheal intubation significantly increased (p<0.05) and remained increased for 3 minutes after the level of preinduction value withine a minute. In group II, blood pressure continued to
decrease
and 5 minutes after intubation, it decreased significantly compared to the preinduction value (p<0.05) In group III. once the blood pressure returned to the preinduction level, it remained.
2) Diastolic blood pressure during endotracheal intubation significantly increased (p<0.05) and remained increased for 3 minutes. It recovered to the level of preinduction value in a minute in group II and III. In group II, it still decreased as
the
time pass but in group III, it remained at the same level of preinduction value once it reached the level.
3) Heart rate is increased during endotracheal intubation in all groups it returned to the level of preinduction value in 5 minutes after intubation. In group I, but it took just 3 minutes in group II & III.
4) Transient change in ECG are noticed in 8 patients of group 1, 4 in group II and 3 in group III.
From above results, the conclusion in drawn that intravenous injection of lidocaine and additional administration of thiopental sodium inhibit increase in blood pressure during the endotracheal intubation. It is thought to be effective to induce
rapid
recovery and to maintain the preinduction level, and to obtuned over increase in blood pressure.
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